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The presence of arginine in its structure contributes to its neuroprotective properties, as arginine-rich peptides have demonstrated abilities to reduce excitotoxicity, diminish mitochondrial dysfunction, and inhibit activation of extracellular matrix metalloproteinases in neuropathology

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The NAD + -consuming enzymes produce NAM as a byproduct, of which high concentrations inhibit the activity of NAD + -consuming enzymes, providing feedback regulation